Appointments: 314-289-6335
Fax: 314-289-7047
e-mail: hmolina@dom.wustl.edu

Currently I am involved in clinical investigation and patient care. My research involves studying possible pathogenic mechanisms involved in the development of Gulf War Syndrome.

2. Molina H. Perkins SJ. Guthridge J. Gorka J. Kinoshita T. Holers VM. Characterization of a complement receptor 2 (CR2, CD21) ligand binding site for C3. An initial model of ligand interaction with two linked short consensus repeat modules. Journal of Immunology. 154(10):5426-35, 1995 May 15. Abstract

3. Kim, Y.-U., Kinoshita, T., Molina, H., Hourcade, D., Tsukasa, S., Wagner, L.M., and Holers, V.M. Mouse complement regulatory protein Crry/p65 uses the specific mechanisms of both human decay-accelerating factor and membrane cofactor protein. J. Exp. Med. 181:151 1995. Abstract

4. Molina, H., Holers, V.M., Li, B., Fung, Y.F., Mariathasan, S., Goellner, J., Strauss-Schoenberger J., Karr, R.W., and Chaplin, D.D. 1996. Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2. Proc. Natl. Acad. Sci. USA 93:3357. Abstract

5. Matsumoto M. Fu YX. Molina H. Chaplin DD. Lymphotoxin-alpha-deficient and TNF receptor-I-deficient mice define developmental and functional characteristics of germinal centers. [Review] [40 refs] Immunological Reviews. 156:13744, 1997 Apr. Abstract

6. Fu YX. Huang G. Matsumoto M. Molina H. Chaplin DD. Independent signals regulate development of primary and secondary follicle structure in spleen and mesenteric lymph node. Proceedings of the National Academy of Sciences of the United States of America. 94 (11):573943, 1997 May 27. Abstract

7. Fu YX. Molina H. Matsumoto M. jug G. Min J. A. Lymphotoxin-alpha (LT-alpha) supports development of splenic follicular structure that is required for IgG responses. Journal of Experimental Medicine. 185(12):2111-20, 1997 Jun 16. Abstract

8. Matsumoto M. Fu YX. Molina H. Huang G. Kim J. Thomas DA. Nahm MH. Chaplin D. Distinct roles of lymphotoxin alpha and the type I tumor necrosis factor (TNF) receptor in the establishment of follicular dendritic cells from non-bone marrow-derived cells. Journal of Experimental Medicine. 186(12):1997-20()4, 1997 Dec 15. Abstract

9. Fang, Y., Xu, C., Fu, Y.-X., Holers, V.M., and Molina, H. 1998. Expression of complement receptors 1 and 2 on follicular dendritic cells is necessary for the generation of a strong antigen- specific IgG response J. Immunol. 160(11):5273-9, 1998 Jun 1. Abstract

10. Nichols, T.C., Guthridge, J.M., Karp, D.R., Molina, H., Fletcher, D. R., and Holers, V.M. 1998.  g - Glutamyl Transpeptidase, an ecto-enzyme   regulator of intracellular redox potential, is a component of TM4 signal transduction complex. Eur. J. Immunol.  28:4123-4129.

11.  Baiu, D.C., Prechl, J., Tchorbanov, A., Molina, H.D., Erdei, A., Sulica,  A., Capel, P.J.A., and Hazenbos, W.L.W. 1999. Modulation of the humoral immune response by antibody-mediated targeting to complement receptors and Fc receptors. J. Immunol. 162:3125-3130.

12. Krych, M., Molina, H., and Atkinson, J.P. 1999. CD35: Complement receptor type 1. J. Biol. Regul. Homeost. Agent 13:229-233.

13.  Kapadia, S.B., Molina, H., van Berkel, V., Speck, S.H., and Virgin, H.B. 1999. Murine g-herpesvirus 68 (gHV68) encodes a functional regulator of complement activation. J. Virol. 73:7658-7670.

14.  Xu, C., Mao, D., Holers, V.M., Palanca, B., Cheng, A., and Molina, H. 2000. A critical role for the murine complement regulator Crry in fetomaternal tolerance. Science 286:498-502.

15.  Jiang, N., and Molina, H. 2000. Genomic organization of the serine protease light chain of mouse complement factor I gene. IUBMB Life 49:109-112.

16.  Wang, Y., Huang, G., Wang, J., Molina, H., Chaplin, D.D., and Fu, Y.-X. 2000. Antigen Persistence is Required for Somatic Mutation and Affinity Maturation of Immunoglobulin. Eur. J. Immunol. 30:2226-2236.

17.  Applequist, S.E., Dahlström, J., Jiang, N., Molina, H., and Heyman, B. 2000. Antibody production in mice deficient for complement receptor 1 and 2 can be induced by IgG/Ag and IgE/Ag but not IgM/Ag complexes. J. Immunol. 165:2398-2403.

18.  Wu, X., Jiang, N., Fang, I., Fu, Y.-X., and Molina, H. 2000. Impaired affinity maturation in Cr2-/- mice is rescue by adjuvants without improvement in germinal center morphology. J. Immunol. 165:3119-3127.

19.  Mellor, A.L., Sivakumar, J., Smith, K., Molina, H., and Munn, D.H. 2000. Tryptophan catabolism protects fetal allografts by inhibiting T cell dependent complement deposition. Nature Immunol. 2:64-68.

20.  Klein, M.A., Kaesrer, P.S., Schwarz P., Weyd, H., Xenarios, I., Zinkernagel, R.M., Carrol, M.C., Verbeek, S., Botto, M., Molina, H., Acha-Orbea, H., and Aguzzi, A. 2001. A role for antibody-independent complement activity in prion disease. Nature Medicine 7:488-492.

21.   Holers, V.M., Girardi, G., Mo, L.,Guthridge, J.M., Molina, H., Pierangeli, S.S., Espinola, R., Xiaowei, L.E., Mao, D., Vialpando, C.G., and Salmon, J.E. 2002. Complement C3 activation is required for antiphospholipid antibody-induced fetal loss. J. Exp. Med. 195:211-220.

22. Miwa, T., Zhou, L., Hilliard, B., Molina, H., and Song, W.-C. 2002. Crry but not CD59 and DAF is indispensable for murine erythrocyte protection in vivo from spontaneous complement attack. Blood 99:3707-3716.

23. Xiaobo W. , Jiang N., Deppong C., Singh J., Dolecki G., Mao D.,  Morel L., and Molina H.  2002. A  role for the Cr2 gene in modifying autoantibody production in SLE. J. Immunol. 169:1587-1592.

24.   Molina, H., Miwa, T., Zhou, L., Hilliard, B., Mastello, D., Maldonado, M.A., Lambris, J.D., and Song, W.C. 2002. Complement-mediated clearance of erythrocytes: mechanism and further delineation of the regulatory roles of Crry and DAF. Blood 100: 4544-4549.

25.   Suresh, M., Molina, H., Salvato, M.S., Mastello, D., Lambris, J.D., and     Sandor, M. 2003. Complement component 3 is required for optimal expansion of CD8 T cells during a systemic viral infection. J. Immunol. 170: 788-794.

26.  Sohn, J.-H., Bora, P.S., Suk, H.-J, Molina, H., Kaplan, H.J., and Bora, N.S. 2003. Tolerance is dependent on iC3b binding to antigen presenting cells. Nature Med. 9:206-212.

27.   Jasinski, M., Pantazopoulos, P., Rother, R.P., Song, W.-C., Molina, H., and  Bessler, M. 2003. Murine red blood cells lacking glycosyl phosphatidylinositol linked proteins have a shortened half-life in circulation independent of complement activation. Blood 103:2827-2834.

28.   Mao, D., Wu, X., Deppong, C., Friend, L.D., Dolecki, G., and Molina, H. 2003. Negligible role of antibodies and C5 in pregnancy loss associated exclusively with C3 dependent effector mechanisms through complement alternative pathway. Immunity  19:813-822.

29. Chen, Y.,  Perry, D.,  Boackle, S.A.,  Sobel, E.S., Molina, H.,  Croker, B.P., and Morel, L. 2005.Several genes contribute to the production of autoreactive B and T cells in the murine lupus susceptibility locus Sle1c. J. Immunol.  175:1080-1089.

30.  Spitzer, D., Unsinger, J., Mao, D., Wu, X., Molina, H., and Atkinson, J.P. 2005. In vivo correction of complement regulatory protein deficiency with an inhibitor targeting the red blood cell membrane. J.Immunol. 175:7763-7770  

31. Thurman, J.M., Ljubanovic, D., Royer, P.A., Kraus D.K., Molina, H., Barry N.P., Proctor, G., Levi, M., and Holers, V.M. 2006.  Altered renal tubular expression of the complement inhibitor Crry permits complement activation after ischemia/reperfusion. J. Clin. Inv. 116:357-368.

 b. Invited publications:

1.  Molina H.D. 1997. Mice deficient in complement receptor 1 and 2 have abnormal B cell responses to T-dependent antigens and impaired germinal center formation in Controlling the complement system for novel drug development, eds. Mazarakis, H., Swart, S.J., and Savage, L. ( IBC’s Library Series, Southborough, MA) pp. 153-179.

2. Holers, V.M., Kinoshita, T., and Molina, H. 1992. Evolution of mouse and human complement C3 binding proteins: divergence of form but conservation of function. Immunol. Today 13:231-236.

3. Matsumoto, M., Fu, Y.-X., Molina, H., and Chaplin, D.D. 1997. Lymphotoxin-a (LTa) deficient and TNF Receptor-I (TNFR-I) deficient mice define developmental and functional characteristics of germinal centers. Immunological Reviews 156:137-144.

4.  Molina, H. 2002. The murine complement regulator Crry: new insights into the immunobiology of complement regulation. CMLS 50:220-229.

5.  Molina, H. 2002. Update on complement in the pathogenesis of SLE. Current Opinion in Rheumatology 14:492-497.

6.  Molina, H. 2004. Complement and immunity. Rheum. Dis. Clin. N.A. 30:1-18.

7.   Molina, H. 2005. Complement regulation during pregnancy. Advances in Experimental Medicine and Biology. 560:149-156.

8. Molina, H. 2005. Arthritis and Rheumatologic Diseases in  Washington Manual of Medical Therapeutics, 32e edited by Daniel Cooper, MD, Andrew Krainik, MD, Samuel Lubner, MD, and Hilary Reno, MD.